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Renal fluoride excretion in children following topical application of fluoride varnish
Pubblication date: 12/2012
Authors: F. García-Hoyos*, E. Barbería**, P. García-Camba***, M. Varela***
Institution: *Department of Odontology, Faculty of Biomedical Sciences, European University of Madrid, Spain
**Program of Integral Dental Treatment of Pediatric Patients,
Department of Prevention, Pediatric Dentistry and Orthodontics
Faculty of Odontology, Complutense University of Madrid, Spain
***Postgraduate Program of Orthodontics,
Fundación Jiménez Díaz, Autonomous University, Madrid, Spain
Publication: European Journal of Paediatic Dentistry
Title: Renal fluoride excretion in children following topical application of fluoride varnish
Abstract: Aim To demonstrate that the application of dental fluoride varnishes in children increases urinary fluoride excretion.
Methods From a randomly assembled group of 42 children aged between 5 and 8 years, residing in a community with non-fluoridated water, spot urinary samples were taken before the topical application of dental fluoride varnish and 2 hours afterwards. In an age-matched control group of 16 children from the same community, who received no treatment, samples were taken the same way. The urinary excretion of fluoride was analysed by determining fluoride ion (F-) level and fluoride/creatinine (F/Cr) ratio in the urine.
Results In the study group, the average pre- and post-treatment F/Cr ratios were 0.42 and 1.38 mg/g, respectively (p < .001). No significant changes were observed in the control group, which received no treatment. The average 2 hours afterward F/Cr ratios were 0.29 and 0.27 respectively (p = 0.426).
Conclusion The topical application of dental fluoride varnish leads to a significant increase in urine F-, which is attributable to the application of the product.