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CPP-ACP and CPP-ACFP versus fluoride varnish in remineralisation of early caries lesions. A prospective study
 

Type:  Articles

Pubblication date:  09/2015

Authors:  C. Llena, A. M. Leyda, L. Forner

Language:  English

Institution:  Department of Stomatology. Universitat de València, Valencia, Spain

Publication:  European Journal of Paediatic Dentistry

Publisher:  Ariesdue Srl

Keywords:  Casein phosphopeptide amorphous calcium phosphate; Casein phosphopeptide amorphous calcium fluoride phosphates; Dental caries; Fluoride varnish; Laser fluorescence; White spot lesion.

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Email:  [email protected]


Title:  CPP-ACP and CPP-ACFP versus fluoride varnish in remineralisation of early caries lesions. A prospective study

Abstract:  Aim To evaluate the effects of novel casein phosphopeptide (CPP) formulations CPP-amorphous calcium phosphate (CCP-ACP) and CPP-amorphous calcium fluoride phosphate (CPP-ACFP) versus fluoride varnish on the remineralisation of enamel white spot lesions (WSLs) over a 12-week follow-up period. Materials and Methods Study Design: Double-blinded prospective study. Eligibility criteria were patients between 6 and 14 years old and have WSLs on their permanent teeth. We evaluated 786 WSLs. Participants were divided randomly into three groups. Groups A and B were instructed to daily topical application of GC Tooth Mouse (CPP-ACP) or Mi Paste Plus (CPP-ACFP), Group C received a monthly professional application of Duraphat fluoride varnish. WSLs were categorised according to the International Caries Detection and Assessment System (ICDAS II; grades 0–3) and assessed by laser fluorescence (DIAGNOdent) at baseline and at 4, 8 and 12 weeks. Changes in mineralisation before and after treatment were analysed using two-way analysis of variance, with post hoc Bonferroni’s non-parametric tests for multiple comparisons. Results DIAGNOdent values were significantly reduced in Group B at 4 weeks, and in Groups A and C at 8 weeks. Mean values in Group B were lower than in Groups A and C at 4 weeks, and lower than Group C at 8 weeks. CPP-ACFP appeared to have a specific effect on smooth-surface caries, but no significant effect on caries in pits and fissures. Conclusions At 4 weeks, CPP-ACFP is superior to fluoride varnish at remineralising smooth-surface WSLs. CPP-ACP is not superior to fluoride varnish by any of the measures studied.

 
 
 
 
 
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