Abstract: Background Mineral trioxide aggregate (MTA), one of the latest materials applied in dentistry, has a variety of potential uses. Numerous studies emphasise its biocompatibility with periodontal and hard tissues, as well as excellent sealing and regeneration abilities.
Case report This article describes the successful therapy of immature mandibular premolars with large open apex, resorption, and endo-perio lesions. In the presented case, the canal was filled with the MTA material. At present, the treated tooth is asymptomatic, and a three-year follow-up radiographic examination demonstrated the dramatic regeneration of periradicular tissues and the new hard tissue formation in the area of the affected teeth.