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Biological effects of resin monomers on oral cell populations: descriptive analysis of literature
Pubblication date: 09/2019
Authors: S. Pagano, M. Coniglio, C. Valenti, P. Negri, G. Lombardo, E. Costanzi*, S. Cianetti, A. Montaseri**, L. Marinucci*
Institution: Department of Biomedical and Surgical Sciences, Odontostomatological University Centre: Chair Prof. Stefano Cianetti, University of Perugia, Perugia, Italy
*Department of Experimental Medicine, Section of Biosciences and Medical Embryology, University of Perugia, Perugia, Italy
**Anatomical Sciences Department, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Publication: European Journal of Paediatric Dentistry
Title: Biological effects of resin monomers on oral cell populations: descriptive analysis of literature
Abstract: Aim Recently, the application of restorative materials containing metacrilate monomers in the conservative and paediatric dentistry has focused on the possible negative effects due to the use of these composites. In particular the release of monomers from reconstructions as a result of an insufficient polymerisation, can spread along the mucosal and dental tissues with potential immunological ed cytotoxic effects. Regarding to the importance of this issue, the aim of this study is to provide a descriptive review of the literature on potential local and systemic interactions of metacrylic and acrylic monomers with the immune system, both in vitro and in vivo.
Results The most highly used monomers in composite materials applied in conservative dentistry include: 2-hydroessietil-methacrylate (HEMA), triethylene glycol-dimethacrylate (TEGDMA), bisphenol A glycidyl-methacrylate (BisGMA) and urethane-dimethacrylate (UDMA). Different investigations have been performed for better understanding of the potential side effects of metacrylic monomers on immune system cells. Different factors such as cell population, exposure time and parameters more strictly connected to these materials, such as molecular weight, chemical composition and mechanical characteristics, seem to be directly involved in these reactions.