The effect of nasal midazolam premedication on parents-child separation and recovery time in dental procedures under general anaesthesia

Authors:

ABSTRACT

Aim

For many children medical and dental procedures, unfamiliar dental staff and treatment places are disturbing and
stressful. Stress in children often makes them uncooperative. General anaesthesia is indicated for anxious uncooperative children or
those who are disabled, immature or too young to undergo dental treatment by other means. Moreover parents' separation while
entering the operative room is a traumatic experience for children. Thus premedication such as midazolam is recommended to decrease
child's stress. In these situations the increased recovery time was considered as one of the midazolam side effects. There is no study
that evaluated the effect of midazolam both in parents-child separation and recovery time in long dental procedure. The purpose of this
study was to evaluate the effect of nasal midazolam premedication with placebo on parents-child separation and recovery times in
uncooperative paediatric patients undergoing long-lasting general anaesthesia for dental procedures.

Methods

Study design: This randomised, double-blind study was done on 60 uncooperative patients (ASA physical status I or II) aged 2-4 years
who were scheduled for general anaesthesia for dental treatment. Group A received 0.2 mg/kg intranasal midazolam as premedication,
and group B received the same volume of intranasal placebo 20 minutes before entering the operating room for general anaesthesia.
General anaesthesia was done with the same method for all patients, then parent-child separation and recovery times were compared
between the two groups. Statistical analysis: Statical significance was set at P0.05. Statically analysis was performed using SPSS
version17.Chi-squared and student t-tests were applied to analyse the data.

Results

We found significant differences in parents-
child separation assessment between two groups. Nasal midazolam premedication had a positive effect on parents-child separation; but
there was no significant difference between the two groups in terms of recovery time.

Conclusion

Premedication of nasal
midazolam before induction of general anaesthesia did not prolong recovery time but made the separation of children from their parents
easier by showing a better behaviour.

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